ACC Medical Information

  • ACC Clinical Trials

    see Mitotane Section
  • Search Engine: NIH - Clinical Trials.gov
  • Search Engine: National Cancer Institute
  • Search Engine: Coalition of Cancer Cooperative Groups
  • Italian Protocol - FIRM-ACT Italian Protocol
  • A Study to Determine Safety, Pharmacokinetics and Pharmacodynamics of Intravenous TKM 080301 in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients
  • Molecular Profiling - or  SCRI-CA-001 Study (Formerly known as the Bisgrove Trial).

  • Joyce Ingold RN MSN OCN
    TGen  Clinical Research Services
    Patient Care Coordinator
    Office Phone:  480-323-1339

  • About Mitotane

  • General Mitotane Info
  • Adjuvant Mitotane Treatment for Adrenocortical Carcinoma New England Journal of Medicine
  • Optimal treatment of adrenocortical carcinoma with mitotane
  • Recurrence of adrenal cortical carcinoma following resection: surgery alone can achieve results equal to surgery plus mitotane
  • Mitotane Absorption - Chocolate, Emulsion, and Milk
  • Low-Dose - Monitored Mitotane Treatment Achieves the Therapeutic Range with Manageable
    Side Effects in Patients with Adrenocortical Cancer
  • Cholesterol - Mitotane and Cholesterol

  • More ACC Chemo Articles

  • Overview - Systemic chemotherapy for adrenocortical carcinoma: comparative responses to conventional first-line therapies.
  • Italian Protocol - Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced
    adrenocortical carcinoma: a large prospective phase II trial
  • Combination chemotherapy in advanced adrenocortical carcinoma
  • Mitotane - New England Journal of Medicine: Adjuvant Mitotane Treatment for Adrenocortical Carcinoma
  • Sutent - Metastatic adrenocortical carcinoma treated with sunitinib: a case report.
  • Sutent - Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells
  • Streptozocin and o,p'DDD in the treatment of adrenocortical cancer patients: Long-term survival in its adjuvant use
  • Platinum - Expression of excision repair cross complementing group 1 and prognosis in adrenocortical carcinoma patients treated with platinum-based chemotherapy.
  • Cisplatin Neuropathy Prevention - Cisplatin-induced peripheral neuropathy: Neuroprotection by erythropoietin without affecting tumour growth
  • Thalidomide - CASE 2. Response in a Patient With Metastatic Adrenal Cortical Carcinoma With Thalidomide
  • EGFR - Mutational analysis of the BRAF, RAS and EGFR genes in human adrenocortical carcinomas.
  • IGF - Preclinical Targeting of the Type 1 Insulin-like Growth Factor Receptor in Adrenocortical Carcinoma.
  • IGF - Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors.
  • IGF - Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling.
  • IGF - Preclinical Targeting of the Type 1 Insulin-like Growth Factor Receptor in Adrenocortical Carcinoma.
  • Treatment of advanced adrenocortical carcinoma with erlotinib plus gemcitabine
  • Gemcitabine plus metronomic 5-fluorouracil or capecitabine as a second-/third-line chemotherapy in advanced adrenocortical carcinoma: a multicenter phase II study.
  • Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice
  • Oral gossypol in the treatment of metastatic adrenal cancer
  • Nexava - Sustained remission with the kinase inhibitor sorafenib in stage IV metastatic adrenocortical carcinoma
  • Avastin - Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma.
  • Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro

  • Molecular Profiling for Targetted Therapies

  • ABC News Fighting Disease with DNA
  • Targeted Therapies Overview
  • Predictive markers help oncologists match patients with the most effective treatments.
  • Gene-expression profiling of adrenocortical carcinoma.
  • Molecular Profiling - or  SCRI-CA-001 Study (Formerly known as the Bisgrove Trial).

  • Joyce Ingold RN MSN OCN
    TGen  Clinical Research Services
    Patient Care Coordinator
    Office Phone:  480-323-1339

  • ATAC ACC Tumor Analysis & Tissue Bank - Free for Eligible Patients
  • Molecular Profiling Institute
  • Rational Therapeutics Chemo-Sensitivity Testing
  • Genomic and expression profiling of adrenocortical carcinoma: application to diagnosis, prognosis and treatment. - Full Text $60
  • Analysis by cDNA microarrays of gene expression patterns of  human adrenocortical tumors.
  • Gene Expression Profiling of Human Adrenocortical Tumors Using Complementary Deoxyribonucleic
    Acid Microarrays Identifies Several Candidate Genes as Markers of Malignancy
  • Review: Side Effects of Approved Molecular Targeted Therapies in Solid Cancers
  • Application of ATP based bioluminescence tumor chemosensitivity assay in the chemotherapy of pediatric solid tumor

  • Genetics

  • Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?
  • p53 tetramerization domain mutations: germline R342X and R342P, and somatic R337G identified in pediatric patients with Li-Fraumeni syndrome and a child with adrenocortical carcinoma.